Systemic chemotherapy decreases brain glucose metabolism

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Systemic chemotherapy decreases brain glucose metabolism

OBJECTIVE Cancer patients may experience neurologic adverse effects, such as alterations in neurocognitive function, as a consequence of chemotherapy. The mechanisms underlying such neurotoxic syndromes remain poorly understood. We here describe the temporal and regional effects of systemically administered platinum-based chemotherapy on glucose metabolism in the brain of cancer patients. MET...

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Brain glucose metabolism in thalamic syndrome.

Regional brain glucose metabolism was studied in a case of postischaemic thalamic syndrome. Despite a normal density of the thalamus on MRI and CT images, a 17% relative hypometabolism was found in the posterior thalamus on the affected side. This observation of functional anomalies in the posterior thalamic complex in case of thalamic syndrome is compatible with a deregulated processing of pai...

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Boosting brain glucose metabolism to fight neurodegeneration?

Alzheimer's disease (AD) is the main cause of dementia in the elderly population with increasing prevalence. Despite the huge efforts invested in AD research, no therapeutic breakthrough has been witnessed yet. Likely, novel approaches and sweeping ideas will be necessary to effectively treat AD. Nevertheless, the earlier the disease is detected the more efficacious the therapy is. Early detect...

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ژورنال

عنوان ژورنال: Annals of Clinical and Translational Neurology

سال: 2014

ISSN: 2328-9503,2328-9503

DOI: 10.1002/acn3.121